Endocrine Abstracts

Introduction: Testosterone treatment in patients with hypogonadism has been associated with cardiovascular and prostatic complications.Objective: To describe the evolution of analytical parameters associated to the complications of testosterone treatment in a male population with hypogonadism treated with testosterone. Methods A retrospective, longitudinal study in which the clinical data of male adults with hypogonadism under intramuscular testosterone ...

Introduction: Amiodarone is an antiarrhythmic iodine-rich drug, known to induce thyroid dysfunction both due to its high iodine content and through amiodarone-induced thyrotoxicosis (AIT), being this latter process classified into three different types. Type 1 is associated with increased thyroid hormone synthesis; type 2 is a destructive process with thyroid hormone release and type 3 is thought to be a mixture of the former two. Since treatment options are different, there h...

Background: Takotsubo cardiomyopathy is a rare, acute, nonischemic cardiomyopathy causing transient systolic disfunction of the apical and/or mid segments of left ventricle and is commonly associated with emotional and physical stress. Thyrotoxicosis is a rare cause of this condition, resulting from direct and indirect action of thyroid hormones on the cardiovascular system.Case presentation: A 43-year-old woman presented at emergency room with chest pai...

Hashimoto’s thyroiditis (HT) is the most common chronic autoimmune thyroid disease, which is characterized by alteration of the thyroid function. HT is a multifactorial disorder and several candidate genetic loci have been identified as contributing to HT. The transcription factor Nrf2, encoded by the NFE2L2 gene, is an important regulator of the cellular protection against oxidative stress. The relevance of selenoproteins in follicular thyroid cell physiology and in mole...

Background: Hypomagnesemia is common in patients with diabetes; possibly due to higher renal magnesium excretion in those patients. Hypomagnesemia seems to correlate with poor glycaemic control. The relationship between urinary magnesium (UMg) and glycaemic control is not known. We aimed to study the association between UMg and glycaemic control in a type 1 diabetes (T1D) pediatric population.Methods: Study of a pediatric population with T1D attending th...

Introduction: Hypogonadism is common and occurs prematurely in human immunodeficiency virus (HIV)-infected men, being hypogonadotropic hypogonadism (HH) more frequent. However, HH with very low testosterone has not been described. We present three HIV-infected men with severe HH and normal pubertal development.Case report: Three HIV-infected men, with HIV-1 diagnosis at the ages of 22, 34 and 35 years. Two of them had depressive syndrome, one treated wit...

Introduction: Hyperglycemia (irrespective of the presence of diabetes) has been associated with worse outcomes in hospitalized patients with a variety of diseases, namely critical illness. It is been recently proposed that a relative hyperglycemia – Stress Hyperglycemia Ratio (SHR) – might be even better associated with disease outcomes. We studied how SHR correlated with various morbidity parameters in hospitalized patients due to acute pyelonephritis.<p class="...

Introduction: Spontaneous fertility in Turner syndrome (TS) is rare, due to low or absent ovarian reserve. A greater number of ovarian follicules is present in the cases of gonadal mosaicism, although the accelerated pace of apoptosis remains. Thus, the early referral to reproductive counseling is advisable, ideally soon after diagnosis. The criopreservation of oocytes is one of the options for fertility preservation. The authors present a series of 7 patients with TS admitted...

Background: Amiodarone is an antiarrhytmic drug used mainly in atrial fibrillation. Amiodarone-induced thyrotoxicosis (AIT) is less common than hypothyroidism, but it represents a true therapeutic challenge. AIT can be due iodine load (type 1) or a destructive thyroiditis (type 2).Methods: Retrospective study of patients with AIT, diagnosed between 2010 and 2015, in a central hospital. We reviewed medical records regarding age, gender, amiodarone therapy...

Background: Fine-needle aspiration (FNA) is an important test for triaging patients with thyroid nodules and differentiating benign from malignant disease. According to Bethesda System Classification, the rate of AUS/FLUS is between 3–6% of all FNA. The malignancy risk is of 5–15%. TSH levels might be associated to the likelihood of malignancy in thyroid nodules according to some studies. Our aim was to establish a possible correlation between TSH level and malignanc...